Patients who had already been receiving treatment in some form Atlanta Hammers shirt, that then changed their treatment for the purposes of this study. The variance here was pretty substantial, ranging from moderate to severe MDD symptoms, and systemotology and presentation of MDD were recorded but not described or controlled for. 2: Tiny, tiny N. The participants were a “convenience sample,” a group of folks who were around the clinic and open to new treatment options. But this N is almost absurdly small. This is probably a funding issue, because this kind of research is incredibly expensive, but there’s a limit on the claims you can make after treating 24 people over the course of 2 months. 3: Extraneous variable problems with the N: some had been in pharmacological treatment for MDD prior to signing up for the study, and had ceased that treatment at least 5 half-lives of the meds prior to starting the study. Depending on the anti-depressant used in that treatment, some of this studies treatment effect could be attributed to their bodies expected homeostatic reaction to being off-meds.
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Randomized, not controlled. This is the Atlanta Hammers shirt that makes it read more like an add to me than good research. The participants were TECHNICALLY randomly assigned to 1 of 2 conditions, but the only difference in the conditions was when they received treatment. The authors themselves note that this separation in itself introduced rather than controlled for new variables in the limitations section of the original paper; but it let them use the Science Word so they did it. Which is fine, if a bit cynical. Publish or Perish. 2: Administration of clinical interventions OTHER than the session were not recorded or standardized. That is, some or all of this effect reported could have come from people simply receiving treatment for MDD and we don’t know. The researchers didn’t do an adequate job separating the effect of the Psylocibin intervention from the other interventions, and failed entirely to report the structure of these other interventions.